Artemotil mediates protection in experimental colitis through the induction of Type 1 regulatory T cells

Abstract Artemotil (β-arteether) is a semi-synthetic derivative of artemisinin - natural compound isolated from the plant Artemisia annuaand used worldwide as front-line anti-malarial drug. Besides its effect, several studies have reported potential use an anti-tumor and anti-inflammatory agent. was found to suppress generation function Th1 Th17 while promoting Foxp3+ regulatory T cells (Tregs). The role in modulating functions Type 1 not yet identified. Tr1 are one key cell types that essential for inhibiting inflammatory response through IL-10. In this study, we report additional by selectively inducing induced IL-27 upregulating signature genes such c-maf Prdm1, IRF-1, Batf. We co-administer with anti-CD3 antibody increases induction IL-10 frequency suppressing vivo associated less severe T-cell-induced enteropathy intestinal inflammation. further show chronic colitis model which treatment alleviates signs increased frequencies cells. Taken together, these data suggest provides protection T-cell-mediated increasing expansion This study supported grants Science & Engineering Research Board (SERB), Department Technology (DST), Government India (CRG/2018/002653)